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KMID : 0363219770150010057
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Korean Journal of Dermatology
1977 Volume.15 No. 1 p.57 ~ p.61
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Clinical Effect of Glutathione (Tathion^®) on Melasma
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한지윤/Han, Ji Yoon
박선옥/함정희/국홍일/Park, Sun Ok/Hahm, Jeong Hee/Kook, Hong Il
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Abstract
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Tathion is a tripeptide, reduced form of Glutathione(GSH or r-glutamyl-cysteinyl-glycine).
Glutathione(SH compound) is believed to inhibit melanin formation by combining with the copper in tyrnsinase which is essential in the conversion of tyrosine to, DOPA (3, 4-dihydroxyphenylalanine) and DOPA to DOPA-quinone or by forming complex with the intermediate in the tyrosine-to-melanin reaction.
The effect of Tathion in the treatment of melasma has not been reported in. Korea.
We have observed the effect of Tathion in 150 patients with melasma. After the average duration of 6wks of treatment(50-100mg tree times/daily), we were able to grade the results as follow.
Excellent (Pigmentation almost disappeared) : 17.4 %
Good (Pigmentation markedly improved) : 56.7 %
Fair (Pigmentation slightly improved : 7.3 %
None (No effect) :18.6%
The result showed relatively good effects of Tathion in the treatment of 122pts (81.4 %) with melasma in total.
The brief review of literature on the treatment of melasma was undertaken.
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